Resveratrol News, Advice and Latest Findings
The medical benefits of Resveratrol and where to buy Resveratrol are at your fingertips.

Does Resveratrol offer real health benefits? What are the actual laboratory results of Resveratrol? What is the correct dosage or potency for Resveratrol supplements or tablets and are they safe? As reported in the journal of Nature and the scientific journal Cell, and cited on this Website, Resveratrol has been shown to decrease the onset and progression of cardiovascular disease, inhibit cancer cell and tumor growth, arrest cell dysfunction and cell death -- in all, to thwart disease and prolong life. Sound promising? Explore the latest Resveratrol results and reports and decide for your own good health.

Resveratrol has captured the attention of the world's health and scientific communities since experiments from the Harvard laboratory of David Sinclair first appeared in the journal Nature in 2003. Sinclair's pioneering research demonstrated the life extending benefits of Resveratrol in mice, the first such laboratory tests performed on a species of mammal. These initial results were further duplicated in a 2006 follow-up study again published in Nature. The additional findings showed that obese mice provided with Resveratrol lived an average of 15% longer than obese mice not provided the supplement.

Researcher Johan Auwerx (at the Institute of Genetics and Molecular and Cell Biology in Illkirch, France) published an online article in the journal CELL in November 2006 which showed that mice fed Resveratrol for 15 weeks had better treadmill endurance than those without the Resveratrol supplement.

The effects of Resveratrol have also been shown to interfere with all three stages of carcinogenesis - initiation, promotion and progression. Resveratrol is reported to possess antioxidant and anti-angiogenic properties and is under extensive investigation as a cancer chemopreventive agent.[9]

What's more, Resveratrol was also reported effective against neuronal cell dysfunction and cell death, and help against diseases such as Huntington's disease [10] and Alzheimer's disease.[11]

Research at the Northeastern Ohio Universities College of Medicine and Ohio State University indicate that resveratrol has direct inhibitory action on cardiac fibroblasts and may inhibit the progression of cardiac fibrosis.[12]

Resveratrol is found in the skin of red grapes and as a constituent of red wine. Some suggest it may explain the “French paradox” that the incidence of coronary heart disease is relatively low in southern France despite high dietary intake of saturated fats.

The substance in Resveratrol is classified as a phytoalexin produced by several plants and is sold as a nutritional supplement as the number of beneficial health effects, such as anti-cancer, antiviral, neuroprotective, anti-aging, anti-inflammatory and life-prolonging effects have been reported.

We invite you to learn more about this fascinating and potentially life changing compound by exploring this Web site and exploring the many resources and links cited herein.

If you are overweight, concerned about cardio-health or cancer, or simply looking to transform the latest knowledge from the world of medical science into your personal health advantage, Resveratrol could be for you!

Resveratrol Supplements, Tablets and Formulas - How to Buy Resveratrol

When marketed as a nutritional supplement, Reseveratrol is typically an extract of Polygonum cuspidatum. Extracts are generally standardized to deliver about 8% resveratrol. Some of the products currently marketed have resveratrol in combination with other phytonutrients and vitamins. Most supplements deliver 16 milligrams per serving or higher. There is no typical dosage, but the currently marketed dosages in Resveratrol capsules and Tablets are as follows:

Resveratrol Capsules — 15 mg, 50 mg, 200 mg

Resveratrol Tablets — 10 mg

Functional food products containing resveratrol are also available. Resveratrol is found in grapevines (Vitis vinifera L). It occurs in the vines, roots, seeds and stalks, but its highest concentration is in grape skins. Wine also contains resveratrol. The concentration of resveratrol in red wine is much higher than that of white wine. The main difference between red and white wine production, besides the grapes used, is that for red wine the skins and seeds are involved in the process, while white wine is mainly prepared from the juice, essentially avoiding the use of grape skins and seeds. During the wine making process, resveratrol, as well as other polyphenols, including quercetin, catechins, gallocatechins, procyanidins and prodelphidins (condensed tannins), are extracted from the grape skins via a process called maceration.

References

1. ^ Gu X, Creasy L, Kester A, et al., Capillary electrophoretic determination of resveratrol in wines. J Agric Food Chem 47:3323-3277, 1999
2. ^ Ector BJ, Magee JB, Hegwood CP, Coign MJ. Resveratrol Concentration in Muscadine Berries, Juice, Pomace, Purees, Seeds, and Wines. http://www.ajevonline.org/cgi/content/abstract/47/1/57
3. ^ a b Benitez DA, Pozo-Guisado E, Alvarez-Barrientos A, Fernandez-Salguero PM, Castellon EA (Oct 18 2006). "Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines". Journal of Andrology. PMID 17050787.
4. ^ Faber AC, Chiles TC (Dec 2006). "Resveratrol induces apoptosis in transformed follicular lymphoma OCI-LY8 cells: Evidence for a novel mechanism involving inhibition of BCL6 signaling". International Journal of Oncology 29 (6). PMID 17088997.
5. ^ Riles WL, Erickson J, Nayyar S, Atten MJ, Attar BM, Holian O (21 Sep 2006). "Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells". World Journal of Gastroenterology 12 (35). PMID 17007014.
6. ^ Sareen D, van Ginkel PR, Takach JC, Mohiuddin A, Darjatmoko SR, Albert DM, Polans AS (Sep 2006). "Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells". Investigative Ophthamology & Visual Science 47 (9). PMID 16936077.
7. ^ Tang HY, Shih A, Cao HJ, Davis FB, Davis PJ, Lin HY (Aug 2006). "Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells" 5 (8). PMID 16928824.
8. ^ Aziz MH, Nihal M, Fu VX, Jarrard DF, Ahmad N (May 2006). "Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins". Molecular Cancer Therapeutics 5 (5). PMID 16731767.
9. ^ Saiko P, Horvath Z, Murias M, Handler N, Jaeger W, Erker T, Fritzer-Szekeres M, Szekeres T. "Antitumor Effects of 3,3',4,4',5,5'-Hexahydroxystilbene in hl-60 Human Promyelocytic Leukemia Cells". Nucleosides Nucleotides Nucleic Acids 25 (9). PMID 17065056.
10. ^ Parker JA, Arango M, Abderrahmane S, Lambert E, Tourette C, Catoire H, Néri C. Resveratrol rescues mutant polyglutamine cytotoxicity in C. elegans and mammalian neurons. Nature Genetics 2005 ; 4 : 349-50. PMID 15793589
11. ^ Philippe Marambaud, Study of Alzheimers Disease and Memory Disorders. Journal of Biological Chemistry 2005 ; November 11
12. ^ Olson ER, Naugle JE, Zhang X, Bomser JA, Meszaros JG. Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol. Am J Physiol Heart Circ Physiol 2005 Mar;288(3):H1131-8. PMID 15498824
13. ^ Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24. PMID 12939617
14. ^ Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A "Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate." Current Biology 2006 Feb 7;16 (3):296-300 PMID 16461283
15. ^ Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. "Resveratrol improves health and survival of mice on a high-calorie diet" Nature 2006 advanced publication
16. ^ Kaeberlein M et al. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol. 2004 Sep;2(9):E296. PMID 15328540
17. ^ Kaeberlein et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005 Apr 29; 280(17):17038-45. PMID 15684413.
18. ^ Boocook DJ, et al. Proc Amer Assoc Cancer Res 2006;47:Abstract #5741
19. ^ Wade, Nicholas (Nov 16 2006). "Red Wine Ingredient Increases Endurance, Study Shows". New York Times.
20. ^ Heredia A, Davis C, Redfield R. Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol. J Acquir Immune Defic Syndr. 2000 Nov 1;25(3):246-55. PMID 11115955
21. ^ Faith SA, Sweet TJ, Bailey E, Booth T, Docherty JJ. Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells. Antiviral research 2006 Jul 14 PMID 16876885
22. ^ Palamara AT, Nencioini L, Aquilano K, et al. Inhibition of influenza A virus replication by resveratrol. Journal of Infectious Diseases May 2005 15;191(10):1719-29. PMID 15838800
23. ^ Gehm BD, McAndrews JM, Chien P, Jameson JL. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. National. Academy of Sciences 1997 Dec 9;94(25):14138-43. PMID 9391166
24. ^ Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology 2000 Oct;141(10):3657-67. PMID 11014220

* Gescher AJ, Steward WP. Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol Biomarkers Prev. 2003;12(10):953-957. Free full text
* Sinclair, David A., et al. "Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase." Science 305 (July 16 2004): 309-392.
* Wolf, George. "Calorie Restriction Increases Life Span: A Molecular Mechanism." Nutrition Reviews 64.2 (Feb. 2006): 89-92
Red Wine Ingredient May Fight COPD WebMD, October 27, 2003

Common misspellings of Resveratrol include Reseveratol, Resveratol, Resveratral and Resverratrol.